Table 6.

Operating Characteristics comparing the DE and ERD designs for discrete doses.

	Standardized Dose Level	True Prob. of DLT	Percent Patients at Dose Level			Percent Trials with Dose Level as MTD
			DE	ERD	DE	ERD
True MTD −0.16	−0.125	0.356	36.500	82.850	71.7	96.9
	0.000	0.450	51.000	15.250	27.6	3.1
	0.200	0.605	10.200	1.780	0.7	0.0
	0.400	0.742	1.970	0.130	0.0	0.0
	0.600	0.844	0.330	0.000	0.0	0.0
	0.800	0.910	0.030	0.000	0.0	0.0
	1.000	0.950	0.003	0.000	0.0	0.0
	1.250	0.977	0.000	0.000	0.0	0.0
Average % DLTs: DE 42.4, ERD 36.2; % trials w. DLT rate > θ + 0.1: DE 52.3, ERD 23.5
True MTD 0.52	−0.125	0.030	0.000	2.080	0.0	0.0
	0.000	0.050	8.273	21.380	0.0	2.3
	0.200	0.111	13.843	39.950	9.4	43.4
	0.400	0.229	40.977	30.170	61.4	48.6
	0.600	0.414	28.863	5.890	27.9	5.4
	0.800	0.627	6.273	0.490	1.3	0.3
	1.000	0.800	1.647	0.040	0.0	0.0
	1.250	0.922	0.123	0.000	0.0	0.0
Average % DLTs: DE 28.5, ERD 15.1; % trials w. DLT rate > θ + 0.1: DE 0.1, ERD 0.0
True MTD 1.22	−0.125	0.007	0.000	0.350	0.0	0.0
	0.000	0.010	6.830	11.130	0.0	0.0
	0.200	0.019	3.680	10.760	0.0	0.1
	0.400	0.035	4.230	15.330	0.0	2.7
	0.600	0.065	5.750	21.330	0.7	16.4
	0.800	0.116	11.470	21.400	7.3	38.2
	1.000	0.200	28.140	14.700	40.9	34.2
	1.250	0.358	39.910	5.000	51.1	8.4
Average % DLTs: DE 21.9, ERD 9.5; % trials w. DLT rate > θ + 0.1: DE 0.0, ERD 0.0