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. Author manuscript; available in PMC: 2019 Aug 2.
Published in final edited form as: Virus Res. 2017 Sep 1;254:21–26. doi: 10.1016/j.virusres.2017.08.018

Figure 1. ZIKV antagonism of type I IFN signaling.

Figure 1

RIG-I and MDA5 are thought to be the primary pattern recognition receptors that recognize ZIKV RNA in the cytoplasm. This leads to the activation of latent transcription factors, IRF-3 and NF-kB and subsequent transcription of IFN-b, proinflammatory cytokines and ISGs. Type I IFN is subsequently translated and secreted from the cell and binds to the type I IFN receptors. This leads to activation of JAK/STAT signaling and formation of the ISGF3 complex that enters the nucleus and binds to interferon-stimulated response elements and enhances expression of hundreds of ISGs. ZIKV proteins or processes within the type I IFN signaling cascade are noted.