Appendix Table 2.

Transition parameters for India example¹

Description	Value			Reference
Sputum smear test
Sensitivity	0.60			[30]
Specificity	0.98			[30]
Cure and default in first-line treatment
Cumulative probability of cure	After Month:	DS	DR	[37]
	1	0.35	0.00
	2	0.88	0.00
	3	0.97	0.00
	4	1.00	0.30
	5	1.00	0.30
	6	1.00	0.30
Monthly probability of default	Age	Males	Females	[3,26,32]
	0	0.0229	0.0229
	20	0.0222	0.0192
	30	0.0219	0.0173
	40	0.0216	0.0155
	50	0.0212	0.0136
	60	0.0209	0.0118
	70	0.0205	0.0099
Mortality
Monthly mortality in treatment, DS or DR TB	0.0101			[3,26,32]
Monthly mortality, DS or DR TB without treatment (selected ages shown)	Age	Males	Females	[35]
	0	0.0289	0.0290
	10	0.0248	0.0248
	20	0.0249	0.0249
	30	0.0250	0.0249
	40	0.0252	0.0250
	50	0.0257	0.0252
	60	0.0270	0.0264
	70	0.0303	0.0292
	80	0.0360	0.0345
	90	0.0473	0.0462
	99	1.0000	1.0000
Monthly mortality, no TB and no treatment (selected ages shown)	Age	Males	Females	[48]
	0	0.0043	0.0044
	10	0.0001	0.0001
	20	0.0002	0.0002
	30	0.0003	0.0002
	40	0.0005	0.0003
	50	0.0010	0.0006
	60	0.0024	0.0018
	70	0.0057	0.0047
	80	0.0116	0.0100
	90	0.0231	0.0220
	99	1.0000	1.0000

¹Transition probabilities for calculation of the post-first-line treatment dynamics, used in the simulation that generates lifetime costs and QALYs, are given in Suen et. al [14]