Table 1.
Association of mixed PRH1, PRH2 genotypes with caries in Swedish children.
| Genotypea | DeFS-12yb |
DeFS-17yb |
ΔDeFSc |
||||||
|---|---|---|---|---|---|---|---|---|---|
| n | mean ± SD | pd | n | mean ± SD | pd | n | mean ± SD | pd | |
| Whole sample | |||||||||
| P4a | 75 | 3.1 ± 3.1 | 0.008 | 65 | 8.1 ± 8.3 | 0.004 | 65 | 4.7 ± 6.6 | 0.102 |
| P6 | 102 | 2.3 ± 2.5 | 0.285 | 93 | 6.1 ± 6.7 | 0.209 | 93 | 3.6 ± 5.8 | 0.477 |
| P1 | 115 | 1.9 ± 2.3 | Ref. | 96 | 4.9 ± 5.7 | Ref. | 96 | 3.0 ± 4.7 | Ref. |
| P4a− | 279 | 2.2 ± 2.4 | 0.022 | 245 | 5.8 ± 6.8 | 0.024 | 245 | 3.6 ± 5.6 | 0.214 |
| Orthodontic treatmente | |||||||||
| P4a | 11 | 4.6 ± 3.9 | 0.032 | 11 | 10.6 ± 6.0 | 0.002 | 11 | 5.5 ± 5.0 | 0.021 |
| P6 | 14 | 2.4 ± 2.4 | 0.382 | 14 | 5.6 ± 8.2 | 0.631 | 14 | 2.7 ± 5.4 | 0.923 |
| P1 | 20 | 1.9 ± 2.4 | Ref. | 18 | 3.3 ± 3.1 | Ref. | 18 | 1.4 ± 2.2 | Ref. |
| P4a− | 47 | 2.2 ± 2.3 | 0.040 | 43 | 5.2 ± 6.0 | 0.005 | 43 | 2.7 ± 4.4 | 0.044 |
Virtually identical results were obtained for P4a (13 children) vs. P1 (23 children) in the whole sample; ΔDeFS ± SD 5.34 ± 4.82 vs. 1.33 ± 2.16, p = 0.016.
a
Swedish ethnicity (n = 369). Mixed acidic PRP phenotypes from PRH1, PRH2 genotyping.
b
DeFS, decayed, enamel included, filled surfaces.
c
ΔDeFS = 5 year caries increment.
d
p-Values were obtained using the Mann-Whitney U test compared to the reference (Ref.).
e
Children treated with orthodontic multibrackets between 12 and 17 years of age.