Table 1.

List of 25 genome-wide significant SNPs in 23 loci that are associated with HR increase or HR recovery

CHR	SNPs	Position (hg19)	EA(Freq)/NEA	Beta	SE	p	Candidate gene	Primary Trait
1	rs11589125	31894396	T(0.06)/C	0.075	0.013	6.60 × 10−09	SERINC2 n,c	HRR50
1	rs272564	45012273	A(0.71)/C	0.046	0.007	1.40 × 10−12	RNF220 n,h	HRR50
1	rs61765646	72723211	A(0.19)/T	0.056	0.008	1.10 × 10−13	NEGR1 n	HRR10
2	rs1899492	60000304	T(0.47)/C	0.040	0.006	1.70 × 10−11	Gene desert	HRR40
2	rs17362588	179721046	G(0.92)/A	0.062	0.011	3.10 × 10−09	CCDC141n,c,TTNh	HRR10
2	rs35596070	179759692	C(0.86)/A	0.060	0.008	4.20 × 10−13	CCDC141n,c,TTNh	HRR10
3	rs73043051	18883863	C(0.22)/T	0.041	0.007	7.80 × 10−09	KCNH8 n	HRR50
3	rs34310778	74783408	C(0.43)/T	0.036	0.006	1.00 × 10−09	CNTN3 n,e	HRR30
5	rs4836027	121866990	T(0.68)/C	0.050	0.006	1.70 × 10−15	SNCAIPn,PRDM6n,h	HRinc
5	rs151283	122446619	C(0.72)/A	0.042	0.007	1.60 × 10−10	PRDM6 nh	HRR50
6	rs2224202	102053814	A(0.19)/G	0.043	0.007	5.80 × 10−09	GRIK2 n,h	HRR20
7	rs2158712	26582733	A(0.52)/T	0.045	0.006	2.80 × 10−13	SKAP n,h	HRR10
7	rs180238	93550447	T(0.65)/C	0.043	0.006	2.20 × 10−12	GNG11n,GNGT1n,e,TFPI2n,e	HRR40
7	rs3757868	100482720	G(0.82)/A	0.077	0.008	5.60 × 10−24	SRRTn,e,ACHEn,e,TRIP6e,C7orf43n,e,UFSP1n	HRR40
7	rs1997571	116198621	A(0.58)/G	0.042	0.006	1.70 × 10−12	CAV1n,h,CAV2n,e,h	HRR20
7	rs17168815	136624621	G(0.84)/T	0.062	0.008	1.10 × 10−14	CHRM2 n	HRR50
10	rs7072737	102556175	A(0.11)/G	0.079	0.009	1.10 × 10−17	PAX2 n	HRR40
11	rs7130652	71984398	T(0.07)/G	0.076	0.011	3.40 × 10−11	CLPBn,h,INPPL1n,e	HRR10
12	rs4963772	24758480	A(0.15)/G	0.090	0.008	1.20 × 10−28	BCAT1 n	HRR40
12	rs6488162	33593127	C(0.58)/T	0.103	0.006	2.60 × 10−66	SYT10n,ALG10h	HRR10
12	rs61928421	116227249	C(0.93)/T	0.090	0.012	4.30 × 10−15	MED13L n	HRR40
14	rs17180489	72885471	C(0.14)/G	0.055	0.008	2.50 × 10−11	RGS6 n,h	HRinc
15	rs12906962	95312071	T(0.67)/C	0.048	0.006	2.70 × 10−14	MCTP2 n	HRinc
19	rs12974440	5894386	G(0.92)/A	0.067	0.011	2.40 × 10−10	FUT5n, NDUFA11n,c	HRR10
19	rs12986417	30109533	G(0.65)/A	0.037	0.006	1.00 × 10−09	POP4n,C19orf12h	HRinc

HRinc HR increase, HRRx HR recovery at x seconds, CHR Chromosome, EA effect allele, NEA Non-effect allele, SE Standard error

ⁿ nearest gene or any other gene in 10 kb^c coding variant gene

^e eQTL gene

^h Hi-C long-range interaction gene

More detailed information can be found in Supplementary Table 2 and 3