Figure 6.

In vivo imaging and biodistribution of B₅V₆₀. (A) ELP₇₇ and B₅V₆₀ labeled with FNR 675 were intravenously injected into 5637 tumor xenograft nude mice. Fluorescence images were taken at different time intervals such as 0.1, 1.2, 4, 6, 12, and 24 h to study biodistribution in vivo (n = 10). Scale bar indicates normalized fluorescence intensity. (B) Fluorescence images of excised organs and tumor at 24 h after intravenous injection. Representative images of subsequent 10 experiments. Scale bar indicates normalized fluorescence intensity. (C) Analysis of fluorescence intensities of excised organs, including tumor tissue (n = 8). *P < 0.05 (Student’s t-test) for ELP₇₇ versus B₅V₆₀.