Figure 5.

(a) Dimensionless concentration of the misfolded tau protein, $n_{\mathrm{mis}}=n_{\mathrm{mis}}^{\ast }/n_{\mathrm{tot},x=0}^{\ast }$, versus position in the axon. At steady state, the production of misfolded tau is balanced by its destruction. (b) Kinetic constant describing the probability of APP transition from the anterograde running state to the free state versus position in the axon. Equation 3.2 was used to simulate the dependence of ${\alpha }_{+}^{\mathrm{\prime }\ast }$ on n_mis. Results are shown at the initial (t* = 0) and steady-state conditions as well as at two intermediate times. (Online version in colour.)