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. 2018 Mar 1;9(3):347. doi: 10.1038/s41419-018-0376-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a WBP2 affects the transcription of ENO1 in U251 and U87 cells. b, c Phosphorylation of Akt and expression of ENO1 measured by western blot using specific antibodies in four cell groups. d Measurements of Enolase-1 activity in different group cells, following an enolase activity assay, e, f Relative glucose uptake and lactate production of eight group cells, assessed by their corresponding detection kits. g, h Relative glucose uptake and lactate production in xenografted tumor. i The proposed model of WBP2-mediated cellular processes in Glioma cells. Tubulin served as the internal control. WBP2 + siNC, EGFP-WBP2 group cells transfected with negative control siRNA; WBP2 + siWBP2, EGFP-WBP2 group cells transfected with WBP2-siRNA; WBP2 + siENO1, EGFP-WBP2 group cells transfected with ENO1-siRNA; WBP2 + siHomer3, EGFP-WBP2 group cells transfected with Homer3-siRNA; WBP2 + W, EGFP-WBP2 group cells treated with wortmannin; WBP2 + siENO1 + W, EGFP-WBP2 group cells transfected with ENO1 siRNA that were pretreated with wortmannin. *P < 0.05, **P < 0.01