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. 2018 Mar 1;8:3873. doi: 10.1038/s41598-018-22217-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Time course of spinal cord injury (SCI)-induced mechanical allodynia and thermal hyperalgesia in wild type (WT) and sigma-1 receptor (σ1R) knockout (KO) mice. Each point and vertical line represents the mean ± standard error of the mean (n = 9–12 per group). a–c: groups not sharing a letter are significantly different, p < 0.05. (A) Mechanical allodynia and (B) thermal hyperalgesia was clearly evidenced on all measurement days in SCI WT mice. The hypersensitivity was attenuated in homozygous σ1R KO mice on days 7, 14 and 28 after SCI.