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. 2018 Mar 1;8:3873. doi: 10.1038/s41598-018-22217-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Spinal ERK1/2 phosphorylation (pERK) expression at day 28 after spinal cord injury (SCI) in wild type (WT) and sigma-1 receptor (σ1R) knockout (KO) mice. Quantification and representative immunoblots of total ERK, pERK and glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Protein expressions were normalized to GAPDH and data is presented as a percentage respect to WT naïve or KO naïve mice (mean ± standard error of the mean; n = 5–6). a–b: groups not sharing a letter are significantly different, p < 0.05; ^#significant differences vs. naïve (p < 0.05). σ1R KO mice subjected to a spinal cord contusion did not show significant upregulation of pERK in contrast to WT SCI mice. Full-length blots are presented in Supplementary Figure S1.