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. 2018 Mar 1;8:3895. doi: 10.1038/s41598-018-22193-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gene-responses following cFC are highly correlated in hippocampus (HC) and retrosplenial cortex (RSC). (A) In HC, IEG mRNA levels (Fos, Arc and Npas4) as detected by qPCR are strongly increased 30 mins (all three genes) and 1 hr (Fos, Arc) after cFC training, and return to baseline within 3 hrs. (B) The time-course of IEG induction observed in HC is recapitulated in RSC (n = 8 mice per group for HC and RSC). (C) Venn diagram showing the number of confirmed hits of two replicate RNAseq studies comparing mRNA expression in naïve and fear conditioned mice. All but one gene (Errf1) found in HC are detected in RSC. (D) Correlation of mRNA induction by fear conditioning in HP and RSC. The gene-responses of the 66 confirmed hits in RSC and HC are highly correlated. The greater number of calls in RSC is explained by an overall larger gene-response in this structure.