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. 2018 Mar 1;8:3895. doi: 10.1038/s41598-018-22193-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Blocking NMDA-R impairs memory and blocks IEG induction in HC and RSC. MK801 (0.1 mg/kg, i.p.) injected 30 mins before cFC training does not affect the response to foot-shock during conditioning (A), but it significantly impairs memory when tested 24 hrs but not 1 hr after training (B), n = 8 per treatment group and time-point). The same dose blocks training-induced IEG induction (Fos, Arc and Npas4) in RSC (C, n = 8) and HC (D, n = 6). Mean ± s.e.m. are shown. Significant differences from vehicle control are indicated by an asterisk (*).