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. 2018 Mar 1;8:3845. doi: 10.1038/s41598-018-22216-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Contribution of Na_V1.6 to TTX-sensitive sodium current in small and large DRG neurons in Na_V1.8 driven Nav1.6 knock out mice. (a) Representative traces of TTX-S currents recorded in small DRG neurons from heterozygous Na_V1.8^+/CreNa_V1.6^+/flox (Control, black lines) and Na_V1.8^+/CreNa_V1.6^flox/flox (Na_V1.6^Nav1.8 KO, orange lines) mice. Cells were held at −100 mV and stepped to membrane potentials from −80 to +30 mV in 5 mV increments (100 ms) to record voltage-dependent sodium currents. (b) The current-voltage (I-V) relation curves for TTX-S sodium currents in small Control (n = 13) and Na_V1.6^Nav1.8 KO (n = 15) KO DRG neurons. (c) Current densities of TTX-S sodium currents in small Control (n = 13) and Na_V1.6^Nav1.8 KO (n = 15) DRG neurons. (d) Representative traces of TTX-S sodium currents recorded in large DRG neurons from heterozygous Na_V1.8^+/CreNa_V1.6^+/flox (Control) and Na_V1.8^+/CreNav1.6^flox/flox (Na_V1.6^Nav1.8 KO) mice. Cells were held at −70 mV, prepulsed to −100 mV for 500 ms, and stepped to membrane potentials from −65 mV to +40 mV in 5 mV increments (100 ms) to record the voltage-dependent sodium currents. (e) The current-voltage (I-V) relation curves for TTX-S sodium currents in large Control (n = 5) and Na_V1.6^Nav1.8 KO (n = 7) DRG neurons. (f) Current densities of TTX-S sodium currents in large Control (n = 5) and Na_V1.6^Nav1.8 KO (n = 7) DRG neurons. Data are presented as mean ± SEM. *p < 0.05 based on unpaired t test.