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. 2018 Mar 1;8:3845. doi: 10.1038/s41598-018-22216-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inflammatory and neuropathic pain behaviors in Na_V1.8-Cre driven Na_V1.6 KO mice. (a,b) Behavioral responses of Nav1.8-Cre driven Nav1.6 KO mice (Na_V1.6^Nav1.8 KO, n = 7) and heterozygous control littermates (Control, n = 7) following intra-plantar injection of 5% formalin (10 µl). (c) Mechanical sensitivity measured by von Frey test following intra-plantar CFA injection (Control, n = 7; Na_V1.6^Nav1.8 KO, n = 9). (d) Thermal sensitivity measured by Hargreaves test following intra-plantar CFA injection. (Control, n = 7; Na_V1.6^Nav1.8 KO, n = 9). (e) Mechanical sensitivity measured by von Frey test following SNI (Control, n = 8; Na_V1.6^Nav1.8 KO, n = 10). (f) Thermal sensitivity measured by Hargreaves test following SNI (Control, n = 8; Na_V1.6^Nav1.8 KO, n = 10). Color code: Control, black; Na_V1.6^Nav1.8 KO, orange. Data are presented as mean ± SEM. No difference (p > 0.05) was observed based on unpaired t test.