Fig. 7.

LXR activation induces macrophage CH25H protein expression. Peritoneal macrophages isolated from C57BL/6 wild-type mice (A, B) or RAW264.7 macrophages (C, D) were treated with T317, GW3965, and 25-HC at the indicated concentrations for 16 h (A, C), or with T317 (200 nM), GW3965 (200 nM) and 25-HC (2 μM) for the indicated times (B, D). Expression of CH25H protein was determined by Western blot. ^aP < 0.05, ^bP < 0.01 vs. control (n = 3).