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. Author manuscript; available in PMC: 2018 Apr 23.
Published in final edited form as: Nat Microbiol. 2017 Oct 23;3(1):73–82. doi: 10.1038/s41564-017-0043-0

Figure 5. C. albicans double adhesin deletion matrix highlights critical factors and genetic interactions for biofilm growth.

Figure 5

(a) Heatmaps depicting average genetic interaction scores (ε) of single and double adhesin gene deletions grown on a polystyrene, PVC, or silicone biofilm. ε is defined as the difference between the measured fitness and the expected fitness based on a multiplicative model, where fitness is defined as optical density (OD) at 490nm of the mutant and normalized to OD of the wild-type parental strain (see Methods). Blue represents a negative interaction score and red represents a positive interaction score; values along the diagonal are zero, indicating no interaction for single knockouts. (b) Genetic interaction map in which red indicates a significantly positive interaction and blue represents a significantly negative interaction. Significant positive interactions are defined as an adjusted p-value<0.05 and ε>0; significant negative interactions are defined as an adjusted p-value<0.05 and ε<0. The maps were generated using Cytoscape

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