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. 2018 Feb 14;4(2):298–305. doi: 10.1021/acscentsci.7b00593

Figure 4.

Figure 4

Interfaces of the K-Ras4B–membrane and C-Raf–membrane interactions. (a) Frequency of K-Ras4B–membrane contacts (residues within 5 Å of membrane surface); position of helices 3–5 is indicated. Inset images show two major orientations of complex relative to the membrane. (b) Frequency of C-Raf–membrane contacts. The region, res. 143–150, is indicated in blue. Inset images: representative orientations of RBD and CRD at the membrane. (c) POPS distribution at the membrane. The distribution is normalized to make the maximum 100%. K-Ras4B CD1 is centered at (0, 0); the horizontal displacement between the center of mass of K-Ras4B CD1 and that of C-Raf RBD is aligned to the x-axis. The last 500 ns of the trajectories were used in these analyses.