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. 2018 Feb 28;7(2):23. doi: 10.1038/s41389-017-0015-5

Fig. 2. Analysis of Src and MEK1/2 inhibitor sensitivity in BRAF-mutant, RAS-mutant, and PIK3CA-mutant cell lines.

Fig. 2

a Cleaved caspase 3/7 activity was measured after a 24 h incubation with either DMSO, 100 nM trametinib, 100 nM dasatinib, or dasatinib+trametinib in the BCPAP, 8505C, T238, Cal62, C643, or THJ16T cell line. Data are represented as means+SEM (n = 3; Student’s t-test; *P < 0.05, **P < 0.005, ***P < 0.0005). b The BCPAP, 8505C, T238, Cal62, C643, or THJ16T cells were treated for 24 h with the indicated inhibitors, and then whole-cell lysates were analyzed by Western blot analysis using the indicated antibodies