Table 2.

Univariate and Multivariate analyses of prognostic factors for cancer specific survival

Variables	Univariate Analysis			Multivariate Analysis
	Hazard ratio	95% CI	P value	Hazard ratio	95% CI	P value
OGN
Low	1 (reference)			1 (reference)
High	0.609	0.378–0.980	0.041	0.523	0.317–0.862	0.011
Gender				NI
Male	1 (reference)
Female	0.816	0.514–1.296	0.389
Age, y	1.017	0.997–1.038	0.103	NI
TNM stage
IV	1 (reference)			1 (reference)
III	0.227	0.141–0.367	< 0.01	–	–
II	0.063	0.029–0.138	< 0.01	0.186	0.075–0.461	< 0.001
I	–	–	0.957			0.969
Grade				NI
Well/ moderate	1 (reference)
poor	1.265	0.805–1.987	0.308
T stage
T2	1 (reference)			1 (reference)
T3	3.927	0.860–17.924	0.077	4.247	0.910-19.829	0.066
T4	9.419	2.306–38.469	0.002	4.258	1.022–17.744	0.047
N stage
N0	1 (reference)			1 (reference)
N1	2.635	1.456–4.768	0.001	0.510	0.234–1.112	0.09
N2	3.713	2.079–6.633	< 0.001	0.595	0.275–1.286	0.186
M stage
M0	1 (reference)			1 (reference)
M1	6.886	4.331–10.95	< 0.001	1.314	0.522–3.306	0.562
Lymph node examined	0.963	0.925–1.002	0.065	NI
Histological type				NI
Adenocarcinoma	1 (reference)
Mucinous	0.842	0.308-2.304	0.738
Perineural invasion
Negative	1 (reference)			1 (reference)
Positive	1.798	1.061–3.045	0.029	1.305	0.750–2.272	0.346
Vascular invasion
Positive	1 (reference)			1 (reference)
Negative	0.443	0.283–0.692	< 0.01	1.058	0.640-1.750	0.827
Adjuvant CT
No	1 (reference)			1 (reference)
Yes	6.366	3.914–10.356	< 0.01	1.945	1.228–3.080	0.005
MS status/MMR status				NI
MSS/MMR-proficient	1 (reference)
MSI/MMR-deficient	0.946	0.599–1.493	0.811

MMR indicates mismatch repair, MS microsatellite, MSS microsatellite stability, MSI microsatellite instability