Table 3.
Logistic regression of each polymorphism in cases (chronic HCV-infected patients) versus controls (uninfected individuals)
| Factor | Univariable Models | Multivariable Model | ||||
|---|---|---|---|---|---|---|
| Estimate | OR (95% CI) | p value | Estimate | OR (95% CI) | p value | |
| rs12979860 | ||||||
| CC | NA | 1 | NA | 1 | ||
| TT | 1.095 | 2.988 (1.208–7.395) | 0.018* | 1.755 | 5.783 (1.279–26.142) | 0.023* |
| TC | 0.550 | 1.732 (0.879–3.415) | 0.113 | 1.127 | 3.086 (1.247–7.642) | 0.015* |
| rs 8,099,917 | ||||||
| TT | NA | 1 | NA | 1 | ||
| GG | 1.007 | 2.738 (0.886–8.454) | 0.080 | −0.240 | 0.787 (0.141–4.375) | 0.784 |
| TG | −0.124 | 0.883 (0.451–1.730) | 0.717 | −0.672 | 0.511 (0.197–1.325) | 0.167 |
| Age | 0.051 | 1.052 (1.023–1.082) | <0.001* | 0.036 | 1.037 (1.008–1.067) | 0.012* |
| Gender | −0.516 | 0.597 (0.312–1.141) | 0.118 | 0.546 | 1.727 (0.843–3.537) | 0.135 |
Odds ratio were constructed considering favourable genotypes (rs12979860-CC and rs 8,099,917-TT) as reference. OR: Odds ratio; CI: Confidence Interval; *p < 0.05