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. 2018 Mar 2;10:30. doi: 10.1186/s13148-018-0458-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Association between epigenomic modification and gene expression. a, b Correlations between epigenomic modification (a is 5-mC, b is 5-hmC) and gene expression in TSS (defined as − 500 bp to + 500 bp across TSS) and genebody respectively. For Medip, there is a clear anti-correlation of gene expression in TSS and a positive correlation in the genebody. For hMedip, only positive correlations in the genebody can be observed. c 5-mC is enriched in the TSS flanking region (defined as − 500 bp to + 500 bp across TSS) of lowly expressed genes in both despite normal and tumor tissues. d 5-hmC is enriched in the genebody region of highly expressed genes in both normal and tumor tissues