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. 2018 Mar 2;19:37. doi: 10.1186/s12931-017-0702-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Effects of PM2.5 on the Shh pathway in HBSMCs. a TAPM2.5 and (b) WSPM2.5 increased Shh and Gli1 expression in HBSMCs in a time-dependent manner. c TAPM2.5 and (d) WSPM2.5 increased Snail expression in HBSMCs in a time-dependent manner. e and f Cyclopamine significantly attenuated the effects of TAPM2.5 and WSPM2.5 on Gli1 expression, but had no effect on Shh expression. g and h Cyclopamine significantly attenuated the effects of TAPM2.5 and WSPM2.5 on Snail expression. i and j siRNA knockdown of Gli1 significantly attenuated the effects of TAPM2.5 and WSPM2.5 on Gli1 expression. k and l siRNA knockdown of Gli1 significantly attenuated the effects of TAPM2.5 and WSPM2.5 on Snail expression. *, P < 0.05; **, P < 0.001; #, P < 0.05; ##, P < 0.001 compared with the control group