Fig. 2.

Model of SHAPE data from the Weeks set. a Log-transformed SHAPE reactivities (grey bars) were fitted by PATTERNA using a Gaussian mixture model (black line) summed across ten Gaussian components per state. Reactivities were subsequently broken down into each pairing state using reference structures to assess the accuracy of PATTERNA’s state-dependent models at unpaired (b) and paired (c) nucleotides. Dashed lines correspond to individual Gaussian components