Table 1.
Scoring rules of prognostic scores to predict mortality in patients with COPD
| Score Predictor | GOLD [50, 51] | GOLD (2011–2016) [51] | BODE [17] | BODE upd. [16] | ADO [15] | e-BODE [18] | BODEx [18] | DOSE [27] | SAFE [28] | B-AE-D [23] |
|---|---|---|---|---|---|---|---|---|---|---|
| BMI | 0 (> 21) | 0 (> 21) | 0 (> 21) | 0 (> 21) | 0 (> = 21) | |||||
| 1 (<= 21) | 1 (<= 21) | 1 (<= 21) | 1 (<= 21) | 6 (18.5–21) | ||||||
| 9 (< 18.5) | ||||||||||
| FEV1% pred. | 0 (> = 80%) | 0 (if FEV1pp > = 50 and <= 1 exacerbations per year) | 0 (> = 65%) | 0 (> = 65%) | 0 (> = 81%) | 0 (> = 65%) | 0 (> = 65%) | 0 (> = 50%) | 0 (> = 80%) | |
| 1 (50–79%) | 2 (otherwise) | 1 (50–64%) | 1 (36–64%) | 1 (65–60%) | 1 (50–64%) | 1 (50–64%) | 1 (31–49%) | 1 (50–79%) | ||
| 2 (30–49%) | 2 (36–49%) | 2 (<= 35) | 2 (51–64%) | 2 (36–49%) | 2 (36–49%) | 2 (<= 30) | 2 (36–49%) | |||
| 3 (< 30%) | 3 (<= 35) | 3 (35–50%) | 3 (<= 35) | 3 (<= 35) | 3 (<= 35) | |||||
| 4 (<= 35%) | ||||||||||
| mMRC | 0 (if mMRC > = 2 and CAT > = 10) | 0 (0–1) | 0 (0–1) | 0 (0) | 0 (0–1) | 0 (0–1) | 0 (0–1) | 0 (0–2) | ||
| 1 otherwise | 1 (2) | 1 (2) | 1 (1–2) | 1 (2) | 1 (2) | 1 (2) | 6 (3) | |||
| 2 (3) | 2 (3) | 2 (3) | 2 (3) | 2 (3) | 2 (3) | 10 (4) | ||||
| 3 (4) | 3 (4) | 3 (4) | 3 (4) | 3 (4) | 3 (4) | |||||
| 6MWT (m) | 0 (> = 350) | 0 (> = 350) | 0 (> = 350) | 0 (> = 400) | ||||||
| 1 (250–349) | 4 (250–349) | 1 (250–349) | 1 (300–399) | |||||||
| 2 (150–249) | 7 (150–249) | 2 (150–249) | 2 (200–299) | |||||||
| 3 (<= 149) | 9 (<= 149) | 3 (<= 149) | 3 (<= 199) | |||||||
| Age (years) | 0 (40–49) | |||||||||
| 2 (50–59) | ||||||||||
| 4 (60–69) | ||||||||||
| 5 (70–79) | ||||||||||
| 7 (> = 80) | ||||||||||
| Prev. exacerbation | (See FEV1pp) | 0 (0) | 0 (0) | 0 (0–1) | 0 (0) | |||||
| 1 (1–2) | 1 (1–2) | 1 (2–3) | 3 (1) | |||||||
| 2 (> 2) | 2 (> 2) | 2 (> 3) | 7 (> = 2) | |||||||
| CAT | (See mMRC) | |||||||||
| Smoking | 0 (non- smoker) | |||||||||
| 1 (current smoker) | ||||||||||
| Quality of life (SGRQ) | 0 (<= 30) | |||||||||
| 1 (31–49) | ||||||||||
| 2 (50–64) | ||||||||||
| 3 (> = 65) | ||||||||||
| Total score | 0–3 | 0–3 | 0–10 | 0–15 | 0–14 | 0–12 | 0–9 | 0–8 | 0–9 | 0–26 |
Abbreviations: BMI body mass index, FEV1% pred. forced expiratory volume in 1 s percentage predicted, mMRC modified Medical Research Council dyspnea scale, 6MWT 6-min walk test, CAT COPD Assessment Test, SGRQ Saint George’s Respiratory Questionnaire; previous exacerbations are referred to the previous year, GOLD Global Initiative for Chronic Obstructive Lung Disease, BODE body mass index, airflow obstruction, dyspnea and severe exacerbations, BODE upd. BODE updated, ADO age, dyspnea, airflow obstruction (we use in our analysis the updated version of the ADO score), e-BODE severe acute exacerbation of COPD plus BODE, BODEx body mass index, airflow obstruction, dyspnea, severe acute exacerbation of COPD, DOSE dyspnea, obstruction, smoking, and exacerbation frequency, SAFE Saint George’s Respiratory Questionnaire (SGRQ) score, air-flow limitation and exercise capacity, B-AE-D body mass index, acute exacerbations, dyspnea (we use the optimized version of the score, introduced in the same paper). Missing cells correspond to variables that do not constitute the score of the correspondent column