FIG. 2.

Histology sections of 3D-engineered tissues harvested after 14 days and stained with hematoxylin and eosin. (A) Normoxia tissue with proliferative cells observed on the tissue surface and (B) in between the microbeads (yellow arrows). (C) Hypoxia tissue with a thin layer of cells, resembling the osteoblastic endosteum observed in vivo. (D) Nonproliferative cell bodies (red arrows) with dendritic connections (black arrows) present between microbeads. Voids left by pulled out microbeads are indicated using dashed circles. Scale bar = 20 μm. Color images available online at www.liebertpub.com/tea