Table 3.
Moderating Effects of Childhood Emotional Abuse (EA) Severity on BOLD Signal Contrasts for Unpleasant > Pleasant
| Region | Volume (voxels) |
Coordinate (peak) |
Coordinate (CM) |
Stat (peak) |
P Value (corrected) |
|---|---|---|---|---|---|
| Placebo | |||||
| -(none)- | – | – | – | – | – |
| CORT | |||||
| Left SMA | 3409 | (−4, −17, 62) | (−8, −25, 51) | Z = 4.8 | .01 |
| Cerebellum | 1023 | (24, −33, −47) | (18, −35, −45) | Z = 4.1 | .01 |
| Left Inf. Parietal Lobule | 781 | (−55, −28, 31) | (−46, −39, 33) | Z = 4.4 | .02 |
| CORT vs. Placebo | |||||
| Left BA6--whole clustera | 1425 | (−38, −13, 52) | (−18, 23, 51) | F = 12.4 | .01 |
| --medial aspect (SMA) | – | (−4, −17, 60) | (−6, −17, 58) | F = 10.2 | – |
| Bilateral Thalamus | 1188 | (14, −33, 7) | (4, −25, 5) | F = 11.2 | .02 |
| Right BA6/BA40 | 1148 | (28, −46, 59) | (28, −38, 52) | F = 9.1 | .02 |
SMA, supplementary motor area; BA, Brodmann area; CM, center of mass.
a
The full extent of left BA6 activation for EA × Drug (CORT vs. Placebo) includes both SMA and premotor cortex (PMC), and peak significance falls in PMC. Due to significant main effect of EA on CORT day in SMA and for theoretical reasons (24), we also report coordinates for the local maxima in SMA alone.