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. 2018 Feb 7;9(2):172. doi: 10.1038/s41419-017-0229-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Representative confocal images of DAPI (blue), p53 (green), and COX IV (red) staining in the hippocampal CA1 region. COX IV was used as a mitochondrial marker, and nuclei were counterstained with DAPI. In the merged microphotographs, yellow puncta indicate the co-localization of p53 and mitochondria. b Manders’ overlap coefficient represents the quantification of co-localization of p53 and COX IV. At least ten cells from each group were selected randomly. ^***P < 0.001 vs. sham + vehicle; ^##P < 0.01 vs. I/R + vehicle group