Fig. 1. HMG20A is expressed in both mouse and human islets and is decreased in islets from T2DM donors.

a HMG20A transcript levels were assessed by qPCR in islets, brain, liver, muscle, white adipose tissue (WAT), and brown adipose tissue (BAT) from mice (n = 6). Representative images of b mouse and c human islets co-stained for HMG20A (green) along with INSULIN (INS), GLUCAGON (GLUC) or SOMATOSTATIN (SMT) (red). Nuclei are stained using DAPI (blue). Magnification 40×. White boxes define areas enlarged in panels bellow. d HMG20A mRNA levels were measured by qPCR in human islets isolated from normoglycemic (control) or type 2 diabetic (T2DM) organ donors (n = 7). Data are depicted as dot plots with means ± S.E.M. p values were determined using unpaired two-tailed Student's t-test. **p < 0.01