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. 2018 Feb 7;9(2):182. doi: 10.1038/s41419-017-0258-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a The ITGA6 mRNA levels in 49 pairs of GBC tissues and their corresponding NATs. b The correlation between the expression levels of miR-143-3p and ITGA6 was determined using a linear regression analysis and a paired t test with the same samples used (P < 0.001, r = −0.2177, n = 49; Pearson’s correlation). c Representative IHC micrographs showing ITGA6 protein expression in GBC tissues with high or low miR-143-3p expression. Scale bar, 100 µm. d Scatterplots of the average staining scores of ITGA6 expression in the miR-143-3p-high or miR-143-3p-low tissues (**P < 0.01, n = 25 for miR-143-3p-low group; n = 24 for miR-143-3p high group). (e) Kaplan−Meier overall survival curve of GBC patients based on ITGA6 expression (P < 0.05, n = 49)