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. 2018 Jan 24;9(2):97. doi: 10.1038/s41419-017-0138-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Mice bearing CHIP variants (i.e., Mock, CHIP-WT, or CHIP-4KR) expressing A549 tumor were given intratumoral injections of IFN-α on days 11, 14, 17, and 20. Tumor growth was monitored every 3 days until the end of the study. Values represent the mean ± S.E.M. for four animals per group. b Tumor tissues harvested from each group were visualized. c, d Tumors were harvested on day 21 for histological analysis. H&E staining c and immunohistochemical staining of PCNA d were performed on tumor sections from each group of mice