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. 2018 Feb 15;9(3):269. doi: 10.1038/s41419-018-0302-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, b CCK8 assays were used to detect the effect of simvastatin combined with sorafenib (Raf inhibitor) on the proliferation in HepG2 and SMMC7721 HCC cells. c, d, Colony formation assays were used to detect the effect of simvastatin combined with sorafenib on the survival of HCC cells. e, f WB was used to examine the effect of combined treatment on the core effectors of downstream signaling