Fig. 7. Intestinal Sptlc2 deficiency–mediated lethality can be rescued.

a Kaplan–Meier survival curve for intestine-specific Sptlc2-deficient mice after rescue with antibiotics and dexamethasone, n = 20. b Body weight measurement at day 16. c Western-blot fluorogram and quantification of SPTLC2 in the colon at day 16. d Measurement of total plasma cholesterol, phospholipids, and triglycerides at day 16. e Western-blot fluorogram and quantification of plasma apolipoprotein levels at day 16. Plasma (0.2 µl) was separated by gradient (4–15% acrylamide) SDS-PAGE and subjected to western blotting with polyclonal antibodies against apoA-I, apoB, and apoE. f Plasma LPS levels at day 16. Values represent the mean ± SD, n = 5, *P < 0.05