Fig. 4. MT regulated cell apoptosis, H19, miR-675, let-7a, TP53, NGF levels in U251 cells (*P < 0.05 compared with the control).

a H₂O₂ treatment increased number of SA-b-gal, which was restored by 1 and 10 μm of MT administration. b H19 level in H₂O₂ treatment group was much lower than H₂O₂ plus MT treatment group; both of them were much lower than control. c miR-675 level in H₂O₂ plus MT treatment group was much lower than control, and was even lower in H₂O₂ treatment group. d let-7a level in H₂O₂ treatment group was much higher than H₂O₂ plus MT treatment group; both of them were much higher than control. e NGF level in H₂O₂ plus MT treatment group was much lower than control, and was even lower in H₂O₂ treatment group. f TP53 level in H₂O₂ treatment group was much higher than H₂O₂ plus MT treatment group; both of them were much higher than control. g Treating with H₂O₂ or H₂O₂ plus MT inhibited proliferation of U251 cell, but the inhibition effect of H₂O₂ was much stronger than H₂O₂ plus MT. h Treating with H₂O₂ or H₂O₂ plus MT promoted apoptosis of U251 cell, but the promotion effect of H₂O₂ was much stronger than H₂O₂ plus MT