Fig. 3. Knockdown of GRK5 inhibits xenograft tumor formation in vivo.

a Representative xenograft tumors for indicated cells were shown. b GRK5 knockdown significantly reduced xenograft tumor growth in male nude mice by tumor volume examination. c Depletion of GRK5 significantly suppressed xenograft tumor weights. d Representative images of H&E and Ki67 IHC for xenograft tumor sections. Scale bar: 10 μm. e Quantification data for (d). HPF high power field. *p < 0.05, **p < 0.01, ***p < 0.001, t-test