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. 2018 Jan 19;9(2):47. doi: 10.1038/s41419-017-0067-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Left, comparison of the growth rates and volumes of SKBR3 tumor xenografts, expressing either GFP or GFP-nucleolin (GFP and NCL, respectively; means ± SE; ***p < 0.005; n = 5). Right, changes in volume of either GFP or NCL tumors following treatment with the nucleolin-specific inhibitor GroA (AS1411) (means ± SE; ***p < 0.005—compared to the respective untreated tumors; n = 5). b Upon experiment termination (~20 days), GFP and NCL tumors, either untreated or treated with GroA, were dissected and compared in size. Lower panel, final tumor volumes are presented as means ± SE (*p < 0.05, ***p < 0.005—treated tumors compared to their respective, untreated, controls; ^p < 0.05—comparison between GFP and NCL tumors; n = 5). c Phosphorylation levels of ErbB2 (upper and lower panels) and Erk (upper panel) in dissected tumors, either untreated (upper) or treated with GroA (lower; NCL), were determined using anti-phospho-ErbB2 and anti-phopsho-Erk antibodies, as indicated (means ± SE; ***p < 0.005; n = 5)