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. 2018 Feb 7;9(2):187. doi: 10.1038/s41419-017-0234-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Density scatter plots of CpG methylation levels between mESCs, C-iPSCs, and 4F-iPSCs. Spearman’s R is indicated. b Histograms showing the distribution of CpG methylation levels (%) in mESCs, C-iPSCs, 4F-iPSCs, and MEFs across the entire genome (All), promoters with different CpG density (HCPs, ICPs, and LCPs), interspersed repeat elements (LINEs, SINEs, and LTRs) and other genomic regions excluding promters and LINEs, SINEs, and LTRs. c Pie charts representing the frequency of CpGs grouped by methylation levels