Fig. 8. Clinical significance of the miR-135b–BMAL1–YY1 loop in human PC.

a Representative ISH anaysis of miR-135b and IHC analyses of BMAL1 and YY1 in normal pancreas and in PC tissues with different histological grades. Magnification ×100. b Kaplan–Meier analysis of the correlation between miR-135b/BMAL1/YY1 expressions (mean split) and the OS times of 141 patients from TCGA cohort. c Multivariable analysis was performed in TCGA cohort. The bars correspond to 95% confidence interval (CI). d OS and progression-free survival (PFS) rates in 37 PC patients (cohort 2) received GEM or GEM-based regimens as first-line chemotherapy. Kaplan–Meier survival curves with log-rank test were used for prognostic evaluation in patients stratified by miR-135b/BMAL1/YY1 expression levels. *P < 0.05