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. 2018 Feb 7;9(2):199. doi: 10.1038/s41419-017-0209-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a HCT116 and HCT116 p21−/− cells have been treated with sn38 for 72 h (5 ng/ml) and apoptosis was evaluated by FACS analysis and the detection of subG1 cells (n = 3 ± s.d.). b Phospho-AP2M1 and p21waf1 expressions have been analyzed by western blot in the indicated cells (n = 3). c, d LS174T or HCT116 cells were treated with sn38 in the presence or absence of Akti 1/2 for 72 h (10 µM) and phospho-AP2M1 and p21waf1 expressions were analyzed as described above (n = 3)