Table 3. Reduction in Risk of Amyotrophic Lateral Sclerosis Milestones With Decrease in the Slope of Decline in Percentage Predicted Slow Vital Capacity by 1.5 Percentage Points per Montha.
| Variable | Risk Reduction, % (95% CI) |
|---|---|
| Decline in the ALSFRS-R subdomain or death after 6 mo | 19 (12-25) |
| First onset of respiratory insufficiency or death after 6 mo | 22 (18-27) |
| First occurrence of tracheostomy or death after 6 mo | 23 (19-27) |
| Death at any time after 6 mo | 23 (18-27) |
Abbreviation: ALSFRS-R, Amyotrophic Lateral Sclerosis Functional Rating Scale–Revised.
a
Data are based on a Cox proportional hazards regression model of time to clinical events from the month 6 visit to end of the follow-up period (P < .001 for all comparisons).