Table 1. Cases of MOG-IgG–Associated Seizures Identified on Literature Review^a.

Source	No. of Patients	Age, y/Sex	Ethnicity	Other Antibodies	Type of Seizure	Clinical Syndrome	Cognitive Changes	Disease Course	T2/FLAIR MRI Brain Changes and Location
Hino-Fukuyo et al, 2015	3	12/M; 14/M; 5/M	Japanese	None	NA	ADEM	NA	Monophasic; relapsing; monophasic	Multiple WM, L basal ganglia and bilateral thalami (1 mo after onset); multiple WM, bilateral; basal ganglia (at third attack); unknown
Tsuburaya et al, 2015	1	7/M	Japanese	None	Partial (eye deviation and L arm clonic seizures)	ADEM, ON	No	Relapsing	Plaque involving subcortical WM in the R frontal lobe
Ramberger et al, 2015	22b	NA	NA	None	NA	ADEM	NA	NA	NA
Titulaer et al, 2014	1	4/F	Hispanic	NMDAR	NA	Seizures, hemiparesis; later: mutism, chorea, and orofacial dyskinesia	Yes	Relapsing	Periventricular, basal ganglia, cerebellum, and pons
Ogawa et al, 2017	4	39/M; 36/M; 23/M; 38/M	Japanese?	None	GTC; GTC; GTC+ focal; GTC	Encephalopathy, ON; seizure, ON; encephalopathy; seizure, aphasia, and R hemiparesis	Yes; during seizure; yes; during seizure	All monophasic	R frontoparietal cortex; L hemisphere cortex
Fujimori et al, 2017	1	46/M	Japanese	None	Focal progressed to secondary generalized	Encephalopathy, paraplegia	Yes	Relapsing	Bilateral frontal cortex, corpus callosum

Abbreviations: ADEM, acute disseminated encephalomyelitis; BG, basal ganglia; CBA, cell-based assay; F, female; FLAIR, fluid-attenuated inversion recovery; GTC, generalized tonic-clonic; L, left; M, male; MOG, myelin oligodendrocyte glycoprotein; MRI, magnetic resonance imaging; NA, not available; NMDAR, N-methyl-d-aspartate receptor; R, right; ON, optic neuritis; WM, white matter.

^aAll studies used a cell-based assay for MOG antibody testing.

^bRepresents patients who presented with 1 or a combination of cognitive impairments or seizures. It is unclear how many of these patients had seizures.