Table 1. Baseline Demographic and Clinical Characteristics of Study Participants.
| Characteristic | HIV-Positive Participants (n = 48) |
HIV-Negative Participants (n = 31) |
P Valuea |
|---|---|---|---|
| Age, mean (SD), y | 47.7 (13.2) | 51.2 (12.9) | .25 |
| Male sex, No. (%) | 25 (52) | 15 (48) | .93 |
| Race/ethnicity, No. (%) | |||
| White | 15 (31) | 16 (52) | .12 |
| African American | 33 (69) | 15 (48) | |
| Educational level, mean (SD), y | 13.3 (3.4) | 14.5 (2.1) | .09 |
| WRAT-3 reading score, mean (SD) | 43.8 (8.9) | 48.1 (6.1) | .09b |
| Current CD4 count, median (IQR), cells/μL | 630 (486, 881) | NA | NA |
| Nadir CD4 count, median (IQR), cells/μLc | 190 (57-300) | NA | NA |
| Estimated duration of HIV infection, median (IQR), yd | 13.5 (5.2-20) | NA | NA |
| Hepatitis C coinfection, No. (%) | 1 (2) | 0 | .30 |
| CPE score, median (range) | 7.5 (5-13) | NA | NA |
| Past substance use, No. (%)d | |||
| Marijuana | 5 (10) | 3 (10) | .90 |
| Methamphetamines | 1 (2) | 1 (3) | .80 |
| Opiates | 1 (2) | 1 (3) | .80 |
Abbreviations: CPE, Central Nervous System Penetration Effectiveness; IQR, interquartile range; NA, not applicable; WRAT-3, Wide Range Achievement Test.
a
P value determined using t test (age and education) or χ2 test (sex, race/ethnicity, past substance use, and hepatitis C coinfection), unless otherwise stated.
b
P value computed from a linear regression model. The WRAT-3 reading score was the dependent variable and HIV serostatus, age, sex, and educational level were independent variables.
c
A total of 7 participants were missing nadir CD4 count.
d
Based on patient’s self-report.