Table 3. Results From Secondary Analyses That Expanded the Population by Including Patients Who Had Used Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers in the Past 180 Days.
Variable | Ramipril (n = 8656) |
Telmisartan (n = 8656) |
---|---|---|
Composite End Point | ||
No. of person-years | 10 227 | 8749 |
No. of events | 799 | 695 |
Incidence rate per 1000 person-years | 78.13 | 79.44 |
Unadjusted | 1 [Reference] | 0.96 (0.89-1.04) |
PS matched | 1 [Reference] | 0.97 (0.88-1.08) |
Stroke | ||
No. of person-years | 10 760 | 9098 |
No. of events | 184 | 173 |
Incidence rate per 1000 person-years | 17.1 | 19.01 |
Unadjusted | 1 [Reference] | 1.08 (0.92-1.27) |
PS matched | 1 [Reference] | 1.07 (0.87-1.32) |
Myocardial Infarction | ||
No. of person-years | 10 755 | 9132 |
No. of events | 156 | 126 |
Incidence rate per 1000 person-years | 14.5 | 13.8 |
Unadjusted | 1 [Reference] | 0.87 (0.72-1.04) |
PS matched | 1 [Reference] | 0.91 (0.72-1.15) |
Hospitalization for Heart Failure | ||
No. of person-years | 10 433 | 8928 |
No. of events | 589 | 481 |
Incidence rate per 1000 person-years | 56.46 | 53.88 |
Unadjusted | 1 [Reference] | 0.93 (0.84-1.02) |
PS matched | 1 [Reference] | 0.91 (0.81-1.03) |
Angioedema | ||
No. of person-years | 10 885 | 9220 |
No. of events | 32 | 10 |
Incidence rate per 1000 person-years | 2.94 | 1.08 |
Unadjusted | 1 [Reference] | 0.43 (0.23-0.82) |
PS matched | 1 [Reference] | 0.35 (0.17-0.71) |
Abbreviation: PS, propensity score.