Table 2. Association of LPA Variants With ASa.
| LPA Variant | Adjusted for Age and Sex (n = 44 703) |
Adjusted for Age, Sex, and Risk Factors (n = 42 535) |
||
|---|---|---|---|---|
| OR (95% CI) | P Value | OR (95% CI) | P Value | |
| rs10455872 | 1.34 (1.23-1.47) | 1.7 × 10−10 | 1.30 (1.18-1.43) | 4.9 × 10−8 |
| rs3798220 | 1.31 (1.09-1.58) | 3.6 × 10−3 | 1.26 (1.04-1.52) | 0.02 |
| Risk score | 1.35 (1.24-1.46) | 1.3 × 10−12 | 1.30 (1.19-1.42) | 1.7 × 10−9 |
Abbreviations: AS, aortic stenosis; OR, odds ratio.
a
Multivariable models were adjusted for dyslipidemia, smoking, diabetes mellitus, and hypertension in addition to age and sex. Odds ratios are per risk allele.