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. 2018 Jan 26;9(2):130. doi: 10.1038/s41419-017-0131-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a The relative expression levels of miR-874 were assessed via qRT-PCR in 120 paired HCC and tumor-adjacent tissues. b Analysis of miR-874 expression in HCC tissues and tumor-adjacent tissues by ISH. c, d Kaplan–Meier analysis revealed five-year OS rates of 22.05 and 38.70% and five-year RFS rates of 11.77 and 31.34% in the low and high miR-874 expression groups, respectively, suggesting that the OS and RFS rates of the low miR-874 expression group were higher than those of the high miR-874 expression group (p < 0.01). e Analysis of DOR expression in HCC tissues and tumor-adjacent tissues by IH. The DOR was overexpressed in cytoplasm of colon cancer tissues but nearly absent from paired tumor-adjacent tissues. f Expression of miR-874 was inversely correlated with the mRNA level of the DOR (r = −0.467, p < 0.01, Spearman’s correlation analysis). Data are shown as the mean ± SD of three replicates (*p < 0.05)