. 2018 Jan 25;9(2):109. doi: 10.1038/s41419-017-0152-y

Table 1.

Subsets and effectors of Breg

Subsets	Mouse	Human	Effector	Different mechanisms should be seperated by ENTER or semicolon.	Reference
Transitional 2 marginal zone precursor B cells/marginal zone precursor B cells	CD21^hiCD23⁺CD24^hiIgM^hiIgD⁺CD1d⁺	CD23⁺sIgM^hisIgD⁺CD21/CD35^hi	IL-10	Suppress Th1/17 and T-cell proliferation (add ENTER or ";")Induce Tr1/Treg cells	50,84,104,105
Marginal zone B cells	CD19⁺CD23^-CD21⁺	–	IL-10	Suppress antigen-specific CD8⁺ T-cell and CD4⁺ T-cell response add ENTER or ";"Induce Tr1 cells	20,31,40
Peritoneal B1a B cells	CD19⁺CD5⁺CD11b⁺	–	IL-10	Regulate neutrophil infiltration (add ENTER or ";") Suppress CD4+ T-cell activation and pro-inflammatory cytokine production	20,51
Plasma cells/plasmablasts	CD138^+/hiCD22^-	CD27^intCD38⁺	IL-35, IL-10, Blimp1, IRF4	Inhibit Th1/17, neutrophils, natural killer cells and dendritic cells (add ENTER or ";") Regulate B cells antigen-presenting ability and pro-inflammatory cytokine secretion (add ENTER or ";")Induce IL-10-producing B cells and IL-35-producing B cells	22,37,46
B10	CD5⁺CD1d^hi	CD5⁺CD1d^hi, CD24^hiCD27⁺	IL-10	Suppress CD4⁺ T cells proliferation and pro-inflammatory cytokine secretion (add ENTER or ";") Suppress antigen-presenting function of dendritic cells Regulate monocyte cytokine production	16,31,39,52,54,55
TIM-1⁺ B cells	CD19⁺TIM-1⁺	CD19⁺TIM-1⁺	IL-4, IL-10	Promote Th2 response (add ENTER or ";") Suppress Th1/17(add ENTER or ";") Suppress antibodies secreted by plasma cells	18,21,60,61,106
Naive B cells/transitional B cells	–	CD19⁺CD24^+/hiCD38^hi	IL-10, TGF-β	Suppress IFN-α production by plasmacytoid dendritic cellsadd (ENTER or ";") Suppress T-cell proliferation, inhibit Th1/17 Induce Tregs and Tr1 cells	24,34,56,58,90,91,107
Circulating B cells	–	CD19⁺CD25^hi CD27^hiCD1d^hi CD86^hi	IL-10, TGF-β	Suppress T-cell proliferation (add ENTER or ";") Induce Tregs	68