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. 2018 Jan 26;9(2):128. doi: 10.1038/s41419-017-0141-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Schematic of the experimental design used to analyze the effect of eltrombopag on the colony-forming potential, proliferation and DNA repair capacity in SAA-iPSC based hematopoietic progenitors; b–d Analysis of CFUs generated in DMSO (dark blue bars) and eltrombopag-treated (orange bars) iPSC-derived-hematopoietic progenitors in WT and SAA cell lines in non-replicative stress conditions; b Total CFUs, c erythroid-lineage CFUs, d myeloid-lineage CFUs. e–g Analysis of CFUs generated in DMSO (red bars) and eltrombopag-treated (grey bars) iPSC-derived-hematopoietic progenitors in WT and SAA cell lines under replicative stress conditions: e Total CFUs, f erythroid-lineage CFUs, g myeloid-lineage CFUs. b–g Multiple t-test using Holm-Sidak method was used for statistical comparison between DMSO and eltrombopag groups. Data is presented as mean of at least 3 independent experiments ± S.E.M. Data for all control cell lines is averaged in one group (WT)