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. 2018 Feb 15;9(3):271. doi: 10.1038/s41419-018-0320-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Representative immunohistochemical images of cytoplasmic, membrane and nuclear staining. b Summary of PEAK1-positive staining data for colon cancer and rectal cancer. c PEAK1 protein expression in 100 colon cancer and 80 normal tissues. Statistical significance was determined by a two-tailed, unpaired Student’s t-test. d PEAK1 protein expression in 83 pairs of rectal cancer. Statistical significance was determined by a two-tailed, paired Student’s t-test. e, f PEAK1 protein expression in colon cancer tissues without lymph node metastasis (N = 60) and with lymph node metastasis (N = 38) and rectal cancer tissues without lymph node metastasis (N = 55) and with lymph node metastasis (N = 28). Statistical significance was determined using a two-tailed, unpaired Student’s t-test. g Kaplan–Meier analysis of overall survival according to low and high PEAK1 protein expression in 100 colon cancer patients. (*P < 0.05, **P < 0.01, ***P < 0.001)