Table 2. Neurocognitive Function Mean (SD) z Scores for Patients and Controls at Each Time Pointa.
| Neurocognitive Domain | Baseline | 6 Months | 12 Months | 24 Months | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P (SD) | C (SD) | d (CI) | P (SD) | C (SD) | d (CI) | P (SD) | C (SD) | d (CI) | P (SD) | C (SD) | d (CI) | |
| Intellectual capacity | 0.55 (0.80) | 0.19 (0.80) | 0.45 (0.31 to 0.60) |
0.45 (0.79) | 0.39 (0.74) | 0.08 (−0.06 to 0.22) |
0.53 (0.74) | 0.57 (0.71) | −0.06 (−0.19 to 0.08) |
0.40 (0.89) | 0.58 (0.69) | −0.22 (−0.38 to −0.06) |
| Concentration/short-term attention span | −0.30 (0.62) | −0.41 (0.56) | 0.19 (0.08 to 0.29) |
−0.28 (0.71) | 0.36 (0.58) | −0.96 (−1.09 to −0.84) |
−0.26 (0.62) | −0.24 (0.66) | −0.03 (−0.15 to 0.09) |
−0.35 (0.77) | −0.20 (0.69) | −0.20 (−0.35 to −0.06) |
| Verbal memory | −1.03 (1.27) | −1.04 (1.08) | 0.01 (−0.21 to 0.22) |
−1.01 (1.25) | −0.76 (1.08) | −0.21 (−0.43 to 0.01) |
−1.08 (1.26) | −0.59 (0.84) | −0.44 (−0.65 to −0.22) |
−1.08 (1.27) | −0.46 (0.94) | −0.54 (−0.77 to −0.31) |
| Visual memory | −0.96 (1.02) | −1.02 (1.05) | 0.06 (−0.12 to 0.24) |
−0.76 (0.92) | −0.96 (0.97) | 0.21 (0.05 to 0.39) |
−0.44 (1.22) | −0.46 (1.08) | 0.02 (−0.21 to 0.24) |
−0.66 (1.11) | −0.34 (1.01) | −0.30 (−0.51 to −0.09) |
| Processing speed | 0.07 (0.77) | 0.08 (0.82) | −0.01 (−0.15 to 0.13) |
0.13 (0.83) | 0.12 (0.82) | 0.01 (−0.14 to 0.16) |
0.13 (0.86) | 0.19 (0.81) | −0.07 (−0.23 to 0.09) |
0.17 (0.88) | 0.25 (0.83) | −0.09 (−0.26 to 0.08) |
| Executive function | 0.09 (0.81) | 0.01 (0.82) | 0.10 (−0.05 to 0.24) |
0.14 (0.73) | 0.03 (0.84) | 0.15 (0.01 to 0.28) |
0.15 (0.78) | 0.16 (0.80) | −0.01 (−0.16 to 0.14) |
0.08 (0.81) | 0.15 (0.78) | −0.09 (−0.25 to 0.07) |
| Motor dexterity | −0.75 (0.85) | −0.53 (0.89) | −0.26 (−0.41 to −0.10) |
−0.69 (0.96) | −0.32 (0.95) | −0.39 (−0.56 to −0.22) |
−0.64 (0.97) | −0.22 (0.95) | −0.44 (−0.62 to −0.26) |
−0.68 (1.03) | −0.18 (0.90) | −0.51 (−0.71 to −0.32) |
| Global cognitive function composite score | −0.33 (0.63) | −0.39 (0.52) | 0.10 (−0.00 to 0.21) |
−0.29 (0.59) | −0.27 (0.53) | −0.04 (−0.14 to 0.07) |
−0.23 (0.63) | −0.08 (0.52) | −0.25 (−0.37 to −0.14) |
−0.31 (0.70) | −0.03 (0.54) | −0.44 (−0.56 to −0.31) |
Abbreviations: C, control group; OR, odds ratio; P, patients; UND, undefined; d, Cohen d effect size.
a
A significant neurocognitive decline is defined as SRB score decrease of ≥1.64 from baseline.