Table 1. Patient Characteristics in the Chemotherapy Plus Radiotherapy (RT) Arm and the Chemotherapy-Alone Arm.
| Variable | Chemotherapy + RT (n = 75) |
Chemotherapy Alone (n = 45) |
P Value |
|---|---|---|---|
| Age, median, y | 52 | 55 | .04 |
| Sex, No. (%) | |||
| Male | 60 (80.0) | 37 (82.2) | .76 |
| Female | 15 (20.0) | 8 (17.8) | |
| Tumor histology, No. (%) | |||
| Urothelial | 41 (54.7) | 23 (51.1) | .71 |
| SCC or other | 34 (45.3) | 22 (48.9) | |
| Tumor grade, No. (%) | |||
| 1 | 1 (1.3) | 3 (6.7) | .12 |
| 2 | 40 (53.3) | 27 (60.0) | |
| 3 | 34 (45.3) | 15 (33.3) | |
| Pathologic T stage, No. (%) | |||
| pT2 | 6 (8.0) | 5 (11.1) | .10 |
| pT3 | 61 (81.3) | 29 (64.4) | |
| pT4a | 8 (10.7) | 11 (24.4) | |
| Tumor size, cm | |||
| Mean | 4.9 | 5.8 | <.01 |
| Median | 5 | 5 | NA |
| Pathologic nodal disease, No. (%) | |||
| Positive | 35 (46.7) | 17 (37.8) | .34 |
| Negative | 40 (53.3) | 28 (62.2) | |
| No. of involved lymph nodes, mean | 1.1 | 0.9 | .29 |
| No. of lymph nodes removed, median | 12 | 12 | .17 |
| ≥10 Lymph nodes removed, No. (%) | |||
| Yes | 54 (72.0) | 27 (60.0) | .17 |
| No | 21 (28.0) | 18 (40.0) | |
| Type of urinary tract diversion, No. (%) | |||
| Ileal conduit | 37 (49.3) | 25 (55.6) | .22 |
| Ureterocolic | 11 (14.7) | 6 (13.3) | |
| Ureterocutaneous | 11 (14.7) | 3 (6.7) | |
| Rectal bladder | 9 (12.0) | 10 (22.2) | |
| Ileocecal conduit | 7 (9.3) | 1 (2.2) | |
| Events, No. (%) | |||
| LF | 2 (2.7) | 13 (28.9) | NA |
| LF only | 1 (1.3) | 12 (26.7) | |
| LF and synchronous DM | 1 (1.3) | 1 (2.2) | |
| DM | 15 (20.0) | 6 (13.3) | |
| Recurrence or death due to progression | 19 (25.3) | 18 (40.0) | |
| Death | 26 (34.7) | 23 (51.1) |
Abbreviations: DM, distant metastasis; LF, locoregional failure; NA, not applicable; SCC, squamous cell carcinoma.