Fig. 1. Conserved regions, functional domains, and genetic mutations in the human STIL protein.

Blue and orange boxes represent regions of the protein that are highly conserved across species (CR conserved region, CC Coiled-Coil domain, STAN STIL/Ana2 domain, KEN Box Conserved Lys-Glu-Asn residues). Double-headed arrows indicate known interactions with STIL. Known phosphorylated residues in 871, 873, 874, 1116, and 1250 are indicated by a red line. Human mutations predicted to truncate the protein are displayed in red and missense mutations are in green